Clinical Pharmacyhttp://ir.haramaya.edu.et//hru/handle/123456789/1972024-03-28T17:44:02Z2024-03-28T17:44:02ZCHEMOTHERAPY MEDICATION ERROR AND ASSOCIATED FACTORS AMONG CANCER PATIENTS ATTENDING AMBULATORY UNIT OF ONCOLOGY WARD AT HARAMAYA UNIVERSITY HIWOT-FANA COMPREHENSIVE SPECIALIZED HOSPITAL, HARAR, EASTERN ETHIOPIANeim Bedewi(Assis Profe) Kirubel Minsamo(Assis Prof) Bisrat Hagoshttp://ir.haramaya.edu.et//hru/handle/123456789/73922024-02-07T06:47:55Z2023-10-01T00:00:00ZCHEMOTHERAPY MEDICATION ERROR AND ASSOCIATED FACTORS AMONG CANCER PATIENTS ATTENDING AMBULATORY UNIT OF ONCOLOGY WARD AT HARAMAYA UNIVERSITY HIWOT-FANA COMPREHENSIVE SPECIALIZED HOSPITAL, HARAR, EASTERN ETHIOPIA
Neim Bedewi; (Assis Profe) Kirubel Minsamo; (Assis Prof) Bisrat Hagos
Cancer patients are at a high risk to encounter Medication errors partly due to
the inherent toxicity and narrow therapeutic index of anti-cancer medications. Thus, assessing
the occurrence of chemotherapy medication errors is crucial to prevent the adverse
consequences. There is limited research available on chemotherapy-related medication errors
in low- and middle-income countries as well as in Ethiopia.
Objective: To assess the prevalence of chemotherapy medication errors and associated factors
among cancer patients attending ambulatory unit of oncology ward at Haramaya University
Hiwot-Fana Comprehensive Specialized Hospital, Harar, Eastern Ethiopia, 2023.
Method: A cross-sectional observational study design was conducted at oncology ward of
Hiwot-Fana Comprehensive Specialized Hospital, Harar, Eastern Ethiopia from 20th January
to 20th March, 2023. Medical records was reviewed to acquire information and an observational
data abstraction tool was developed to obtain data during preparation and administration of
chemotherapy medications. 366 patients were selected by a convenient sampling technique.
Data were coded and interred to Epi-InfoTM V:7.2.5.0 and analysed using STATA version 14.
Descriptive data were summarized using tables, charts and graphs. Bivariable and multivariable
logistic regression analyses was done to identify factors associated with medication error.
Statistical significance was declared at 95% confidence interval with P-value less than 0.05
Results: Prevalence of chemotherapy medication error was 46.99% (95%CI: 41.86%-52.13%).
Patients aged between 41-60 years (AOR=3.93, 95%CI: 1.53-10.22), aged 61 years or older
(AOR=4.79, 95%CI: 1.79-12.81), regimens with four injectable chemotherapy drug (AOR=
5.86, 95%CI: 1.77-19.40), follow-up patients (AOR=2.18, 95%CI: 1.23-3.87), carboplatin based (AOR=4.65, 95%CI: 2.17-9.96), and modified chemotherapy regimen (AOR= 2.68,
95%CI: 1.18-6.08) were statistically associated with medication error at a p-value < 0.05.
Conclusion: In this study, near to half of cancer patients had one or more chemotherapy related
ME. Older age, increased number of IV chemotherapy medications, modified treatment
regimens, carboplatin-based regimens, and being follow-up patient, were all strongly linked
with chemotherapy medication error. There is necessity of developing and implementing
effective strategies to reduce and prevent medication error
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2023-10-01T00:00:00ZChemotherapy Medication Error and Associated Factors among Cancer Patients Attending Ambulatory Unit of Oncology Ward at Haramaya University Hiwot-Fana Comprehensive Specialized Hospital, Harar, Eastern EthiopiaNeim Bedewi(Assis Prof) Kirubel Minsamo(Assist Prof) Bisrat Hagoshttp://ir.haramaya.edu.et//hru/handle/123456789/73532024-01-17T07:35:18Z2023-10-01T00:00:00ZChemotherapy Medication Error and Associated Factors among Cancer Patients Attending Ambulatory Unit of Oncology Ward at Haramaya University Hiwot-Fana Comprehensive Specialized Hospital, Harar, Eastern Ethiopia
Neim Bedewi; (Assis Prof) Kirubel Minsamo; (Assist Prof) Bisrat Hagos
Cancer patients are at a high risk to encounter Medication errors partly due to
the inherent toxicity and narrow therapeutic index of anti-cancer medications. Thus, assessing
the occurrence of chemotherapy medication errors is crucial to prevent the adverse
consequences. There is limited research available on chemotherapy-related medication errors
in low- and middle-income countries as well as in Ethiopia.
Objective: To assess the prevalence of chemotherapy medication errors and associated factors
among cancer patients attending ambulatory unit of oncology ward at Haramaya University
Hiwot-Fana Comprehensive Specialized Hospital, Harar, Eastern Ethiopia, 2023.
Method: A cross-sectional observational study design was conducted at oncology ward of
Hiwot-Fana Comprehensive Specialized Hospital, Harar, Eastern Ethiopia from 20th January
to 20th March, 2023. Medical records was reviewed to acquire information and an observational
data abstraction tool was developed to obtain data during preparation and administration of
chemotherapy medications. 366 patients were selected by a convenient sampling technique.
Data were coded and interred to Epi-InfoTM V:7.2.5.0 and analysed using STATA version 14.
Descriptive data were summarized using tables, charts and graphs. Bivariable and multivariable
logistic regression analyses was done to identify factors associated with medication error.
Statistical significance was declared at 95% confidence interval with P-value less than 0.05
Results: Prevalence of chemotherapy medication error was 46.99% (95%CI: 41.86%-52.13%).
Patients aged between 41-60 years (AOR=3.93, 95%CI: 1.53-10.22), aged 61 years or older
(AOR=4.79, 95%CI: 1.79-12.81), regimens with four injectable chemotherapy drug (AOR=
5.86, 95%CI: 1.77-19.40), follow-up patients (AOR=2.18, 95%CI: 1.23-3.87), carboplatin based (AOR=4.65, 95%CI: 2.17-9.96), and modified chemotherapy regimen (AOR= 2.68,
95%CI: 1.18-6.08) were statistically associated with medication error at a p-value < 0.05.
Conclusion: In this study, near to half of cancer patients had one or more chemotherapy related
ME. Older age, increased number of IV chemotherapy medications, modified treatment
regimens, carboplatin-based regimens, and being follow-up patient, were all strongly linked
with chemotherapy medication error. There is necessity of developing and implementing
effective strategies to reduce and prevent medication error
49p.
2023-10-01T00:00:00ZIN-HOSPITAL MORTALITY AND ITS ASSOCIATED FACTORS AMONG HOSPITALIZED STROKE PATIENTS IN HARAR PUBLIC HOSPITALS, EASTERN ETHIOPIAZiyad Abas HassenDumessa EdessaTigist Gashawhttp://ir.haramaya.edu.et//hru/handle/123456789/72702024-01-16T06:58:17Z2023-10-01T00:00:00ZIN-HOSPITAL MORTALITY AND ITS ASSOCIATED FACTORS AMONG HOSPITALIZED STROKE PATIENTS IN HARAR PUBLIC HOSPITALS, EASTERN ETHIOPIA
Ziyad Abas Hassen; Dumessa Edessa; Tigist Gashaw
Background: Stroke is rapidly developing clinical signs of focal or global disturbance of cerebral function, with symptoms lasting more than 24 hours and leading to death, with no apparent cause other than a pathological process of the blood vessel. Stroke is a public health problem in Ethiopia. According to World Health Organization data published in 2020, stroke deaths in Ethiopia reached 6.98% of total deaths. Despite the high stroke mortality rate in Ethiopia, there is nothing study about in-hospital mortality and its associated factors in eastern, Ethiopia. Objective: To determine in-hospital mortality and its associated factors among hospitalized stroke patients in Hiwot Fana comprehensive specialized university hospital and Jugal general hospital from September 2016–August 2022 G.C. Methods: A retrospective cohort study was conducted in Hiwot Fana comprehensive specialized university hospital and Jugal general hospital. A data collection tool was developed to record relevant information from existing medical records. The sample size of 395 medical records of stroke patients was selected from a total of 564 stroke patients by a simple random sampling technique. The data was entered by Epi Data Manager version 4.6 and analyzed by SPSS version 26. Bivariate and multivariate backward cox-regression analysis were used to verify the associated factors of in-hospital mortality among stroke patients. A p-value of 0.05 at a 95% confidence interval was used to establish a statistically significant association. Results: Of 395 hospitalized stroke patients assessed, 109 (27.6%) of them encountered death within the hospital while 57.2% and 15.2% of them were discharged with improvement and against medical advises, respectively. Age greater than 65 (AHR = 4.71, 95% CI = 1.11-19.96, p = 0.035), was statistically significant association with stroke mortality, while creatinine level >1.2 mg/dl (AHR = 1.54, 95% CI= 1.0-2.39, P = 0.05), and co-morbidity with atrial fibrillation (AHR = 1.48, 95% CI= 1.0-2.21, P = 0.05), where marginally significant association with stroke mortality. Conclusion: In-hospital mortality was found in more than a quarter of stroke patients. This mortality was high and more likely increased among the patients with age > 65, serum creatinine level >1.2 mg/dl, and co-morbidity with atrial fibrillation. Hence, this high-risk patients’ needs to be identified, monitored, followed-up, and aggressively treated to reduce mortality risks. Further prospective research should be conducted to investigate the problem in-depth.
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2023-10-01T00:00:00ZANTIBIOTIC KNOWLEDGE, PRACTICE, AND ASSOCIATED FACTORS IN THE TREATMENT OF ACUTE UPPER RESPIRATORY TRACT INFECTIONS FOR CHILDREN AMONG CAREGIVERS AT HARARI REGION HEALTH FACILITIESChala AbrahimMr. Dumessa EdessaMr. Jemal Abdelahttp://ir.haramaya.edu.et//hru/handle/123456789/72692024-01-16T06:24:08Z2023-10-01T00:00:00ZANTIBIOTIC KNOWLEDGE, PRACTICE, AND ASSOCIATED FACTORS IN THE TREATMENT OF ACUTE UPPER RESPIRATORY TRACT INFECTIONS FOR CHILDREN AMONG CAREGIVERS AT HARARI REGION HEALTH FACILITIES
Chala Abrahim; Mr. Dumessa Edessa; Mr. Jemal Abdela
Background: Acute upper respiratory tract infections are infections caused by viruses or bacteria, and most of the time they are self-limited and treated without the consumption of antibiotics. Due to inadequate knowledge and poor practice, caregivers’ use of antibiotics for these infections in their children promotes the development of antibiotic-resistant bacteria. Overall, there is limited information on caregivers’ knowledge and practice of antibiotic use for children in Ethiopia, particularly in the Harari region, Eastern Ethiopia.
Objective: To assess the current antibiotic knowledge, practice, and associated factors in the treatment of children with acute upper respiratory tract infections by caregivers at health facilities in the Harari region, Eastern Ethiopia, from January 30 to February 28, 2023.
Methods: A facility-based cross-sectional study design was employed by using a structured questionnaire to collect data from a sample of 421 caregivers who were selected by a systematic sampling method from the immunization unit of health facilities. Data were collected and entered into Epi Data, then descriptive and analytical statistics were done using SPSS version 26. A binary logistic regression model with an adjusted odds ratio (AOR) and a 95% confidence interval was used to identify the associated factors with the outcome variables.
Results: Nearly half of the caregivers (48.2%) had poor knowledge of antibiotic treatment, and about 47.2% of them had poor practices. Caregivers’ age (AOR = 1.10, 95% CI: 1.02, 1.16), educational level (AOR = 0.34, 95% CI: 0.13, 0.88), being housewives (AOR = 0.32, 95% CI: 0.13, 0.76), health insurance (AOR = 2.52, 95% CI: 1.32, 4.80), number of under-five children (AOR = 0.64, 95% CI: 0.43, 0.96), and time taken to reach a health facility (AOR = 1.04, 95% CI: 1.02, 1.08) were significantly associated with poor knowledge. Further, educational level (AOR = 0.12, 95% CI: 0.03, 0.45), child's age (AOR = 0.96, 95% CI: 0.93, 0.99), seeking treatment from a pharmacy or drug shop (AOR = 8.22, 95% CI: 1.04, 65.3), and caregivers' antibiotic knowledge (AOR = 0.71, 95% CI: 0.60, 0.82) were significantly associated with caregivers’ poor practice.
Conclusion: This study's findings showed that a significant number of caregivers had poor knowledge and poor practice of antibiotic use. Caregivers' educational level was the main factor significantly associated with caregivers poor knowledge and poor practice. Also, caregivers' antibiotic knowledge was significantly associated with poor practice. To improve caregiver knowledge and practice, sufficient antibiotic drug information provision by healthcare providers is recommended.
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2023-10-01T00:00:00Z