Abstract:
Helicobacter pylori is a small, spiral-shaped bacteria that lives on the surface of the stomach
and duodenum. H. pylori is closely associated with onset of diseases such as gastric ulcers,
duodenal ulcers, gastritis and gastric cancers. The aim of this study was to determine the
allelic and genotypic frequencies of ABO blood group system and their associations with H.
pylori infection among 384 patients with gastrointestinal complaints in the Ejere and Amaro
Helth Center. Stool samples were taken from all patients for detection of H. pylori antigen by
chromatographic immunoassay test. The ABO blood group system was determined by hem
agglutination test. A total of 128(33.3%) of the participants were H.pylori positive. The
phenotypic frequencies of ABO blood group were O-type180 (46%); A-type 101(26); B-type
76(20%); and AB-type 27(7%). The allelic frequencies of ABO blood group of patients were:
I
A
,0.1835; I
B
,0.1454 and I
O
,0.6911 and the genotypic frequencieswere I
A
I
A
,0.0341;I
A
I
O
,0.255
3;I
B
I
B
,0.0211;I
B
I
O
,0.2009;I
A
I
B
,0.0537;I
O
I
O
,0.4776. Patients of blood type-B were more prone
to H. pylori infection, 33(43%), than patients of other blood types, and patients of the AB
blood type were less prone to H. pylori infection, 7 (25%), as compared with patients of other
blood types. The finding of this study indicates that people with blood type-B were more
susceptible to infection with H. pylori than people with other blood types. The results of this
study showed that there was a significant association between A and B blood type and H.
pylori infection, in which type-B has a greater tendency towards infection.
