SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL PROPERTIES OF Ni(II) AND Cu(II) COMPLEXES OF SCHIFF BASE DERIVED FROM FURFURAL SEMICARBAZONE

Abstract

Schiff base ligand and their Metal complex are important compounds owing to their wide range of biological activities. Metal complexes of Cu(II) and Ni(II)have been synthesized from the Schiff base ligand, furfural semicarbazone(L), derived from furfural and semicarbazide hydrogenchloride. Structural features of these complexes were obtained from their elemental analyses, magnetic susceptibility, molar conductance, chloride test, FT-IR, electronic spectra, 1H , 13C NMR and DEPT-135 and Atomic Absorption Spectroscopic studies. The FTIR revealed that the ligand acts as a bidentate ligand coordinating through the oxygen of the carbonyl group and nitrogen of the azomethine group. The synthesized complexes showed the conductivity values of 154.14 and 6.12 S mol-1 cm 2 for [Cu(L)2]Cl2 and [Ni(L)2 Cl2], in DMSO at 25 0C which confirms the electrolytic and non electrolytic nature of the complexes, respectively. On the basis of spectral studies and magnetic susceptibility measurements, an octahedral geometry has been assigned for Ni(II)complex but square planar for Cu(II) complex. Antimicrobial activity test against bacteria (Escherichia coli, Staphylococcus aureus, Streptococcus Agalactia, and Salmonella) and fungi (Aspergillus niger, Fusarium oxisporium) strains revealed that the complexes were more bioactive than the corresponding free ligand and less than the standard drug. Cu (II) complex exhibited higher activity against Aspergillus niger str ain and Ni(II) complex exhibited higher activity against Escherichia coli strain. The biological activity of the ligand was enhanced when it is complexed with metal ions.