Abstract:
Schiff base ligands and their metal complexes are very important in medicinal and
pharmaceutical fields because of their wide spectrum of biological activities. This research
work describes the synthesis, characterization and antimicrobial investigation of Schiff base
ligand derived from p-dimethyl amino benzaldehyde and ethylene diamine and its Co (II) and
Cu (II) complexes. The ligand has been synthesized by condensation of p-dimethyl amino
benzaldeyde and ethylene diamine. The complexes of Co (II) and Cu (II) with the synthesized
ligand were prepared. The synthesized ligand was characterized by NMR spectra. The
synthesized ligand and its complexes were characterized on the basis of elemental analysis,
IR and electronic spectral data. The complexes were also characterized by molar
conductance, AAS, and magnetic susceptibility measurements. Based on the spectral and
analytical data octahedral geometry was proposed for both complexes. The conductivity data
suggests electrolytic nature of both complexes. The antimicrobial activity of the synthesized
ligand L and its Co (II) and Cu (II) complexes were evaluated against four bacteria
(S.aureus, S.gatia, E.coli and S.typhi), and two fungi (A.flavus and A.niger) strains. The
results obtained as such were compared with the values for standards. Both complexes
exhibited higher antibacterial activity than the parent ligand. However the ligand and its
metal complexes have shown no inhibitory effect on the tested fungi.
