SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF Co (II) AND Cu (II) COMPLEXES OF SCHIFF BASE DERIVED FROM p-DIMETHYLAMINO BENZALDEHYDE AND ETHYLENE DIAMINE

Abstract

Schiff base ligands and their metal complexes are very important in medicinal and pharmaceutical fields because of their wide spectrum of biological activities. This research work describes the synthesis, characterization and antimicrobial investigation of Schiff base ligand derived from p-dimethyl amino benzaldehyde and ethylene diamine and its Co (II) and Cu (II) complexes. The ligand has been synthesized by condensation of p-dimethyl amino benzaldeyde and ethylene diamine. The complexes of Co (II) and Cu (II) with the synthesized ligand were prepared. The synthesized ligand was characterized by NMR spectra. The synthesized ligand and its complexes were characterized on the basis of elemental analysis, IR and electronic spectral data. The complexes were also characterized by molar conductance, AAS, and magnetic susceptibility measurements. Based on the spectral and analytical data octahedral geometry was proposed for both complexes. The conductivity data suggests electrolytic nature of both complexes. The antimicrobial activity of the synthesized ligand L and its Co (II) and Cu (II) complexes were evaluated against four bacteria (S.aureus, S.gatia, E.coli and S.typhi), and two fungi (A.flavus and A.niger) strains. The results obtained as such were compared with the values for standards. Both complexes exhibited higher antibacterial activity than the parent ligand. However the ligand and its metal complexes have shown no inhibitory effect on the tested fungi.