Bacterial Isolates, Drugs Susceptibility Pattern and Associated Factors of Neonatal Sepsis in Dire Dawa, Eastern Ethiopia

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dc.contributor.author tesema, Kenesa
dc.contributor.author seyoum, Berhanu Major Advisor (PhD)
dc.contributor.author alemayehu, Tadesse Co Advisor (PhD)
dc.date.accessioned 2018-01-28T20:50:18Z
dc.date.available 2018-01-28T20:50:18Z
dc.date.issued 2017-11
dc.identifier.uri http://localhost:8080/xmlui/handle/123456789/3287
dc.description 67 en_US
dc.description.abstract Neonatal sepsis is characterized by bacteraemia in the first four weeks of life. It is the third most common cause of death in this age group with an estimated 401,000 of deaths in 2015, the vast majority of which are in developing countries. Objective of this study was to determine bacterial isolates, drugs susceptibility pattern and associated factors of neonatal sepsis in Dire Dawa. Cross-sectional study design was employed to collect relevant information using structured check list and about 1ml of blood specimen for culture was drawn from 396 newborn admitted in the neonatal intensive care unit of the hospital during the study period. The specimen was inoculated into brain heart infusion broth and subcultures were performed. The isolates were identified by standard biochemical tests. Antimicrobial susceptibility pattern was studied by Modified Kirby Baur Disc diffusion technique. The data was entered using Epidata version 3.1 & analyzed using SPSS 16.0 software. Bivariate and multivariate logistic regression analysis was performed to evaluate whether individual predictors of interest were independently significantly associated with sepsis. Sepsis was confirmed in 127 neonates (32.10%). Gram negative bacteria dominated the isolates (67.72%) in which K. pneumoniae (34.66%) was the commonest isolate followed by S. aureus (22.83%) from gram positive bacteria. This study also identified infection due to MDR bacteria (77%) that the main isolates, S. aureus (83%) and K. pneumoniae (84%), were the principal MDR strains. Gram positive and gram negative bacteria isolates showed 65%- 85% resistance rates to ampicillin, amoxicillin-clavulanic acid, tetracycline, and ceftriaxone. Gentamycin (93% sensitive) and ciprofloxacin (71% sensitive) were effective against gram positive bacteria; whereas gram negative bacteria were 100% sensitive to ciprofloxacin. Predisposing factors associated with neonatal sepsis were prematurity (AOR = 3.243: 1.534, 6.856), age less than 3 days (AOR = 2.654: 1.483, 4.746), low birth weight (AOR = 4.684: 2.319, 9.460), assisted vaginal delivery (AOR = 3.322: 1.462, 7.549), and resuscitation (AOR = 3.592:1.904, 6.778). This study demonstrated that prematurity and low birth weight were major predisposing factors to neonatal sepsis mainly caused by K. pneumoniae and S. aureu. Implementation of bundle of cares based strategies and regular evaluation is advised. en_US
dc.description.sponsorship Haramaya university en_US
dc.language.iso en_US en_US
dc.publisher Haramaya university en_US
dc.title Bacterial Isolates, Drugs Susceptibility Pattern and Associated Factors of Neonatal Sepsis in Dire Dawa, Eastern Ethiopia en_US
dc.type Thesis en_US


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