Abstract:
Background: Hepatitis B Virus infection and diabetes mellitus are major health problems
associated with significant morbidity and mortality throughout the world. Patients suffering
from Diabetes Mellitus incur high risk of infection with hepatotropic viruses because of
frequent hospitalization.Hepatitis B virus infection can cause chronic hepatitis, cirrhosis or
hepatocellular carcinoma. However, there is limited report on the magnitude of Hepatitis B
virus infection among diabetic patients in eastern part of Ethiopia.
Objective:To assess the prevalenceof Hepatitis B virus infection and associated factors
among diabetic adult patients attending Haramaya General Hospital from August 8 to
August30 2021,G.C.
Methods:An institution-based cross-sectional study was conducted in diabetic clinic
attendants. A total of 365 participants were selected usingconsecutive sampling technique.
Data on socio-demographic feature and other associated factors were collected using a
pretested questionnaire. Blood sample was collected; serum was separated and tested for
HBsAg sero status using rapid diagnostic kit (ACONhepatitis B surface antigen Laboratories
rapid test kit, USA). Data were entered to Epi data version 4.6.0.2 software, exported
toanalyze by SPSS version 26. Logistic regression was used to assess association of HBV Diabetes co-infection with the independent factors. All tests were two-sided with α level of
0.05. A P-value less than 0.05 were considered statistically significant.
Results: In this study, a total of 365 participants were enrolled, 243(66.3%) male, and
122(33.7%) females with a mean age of 42.24 (± SD 10.2). The total seroprevalence of
HBsAg among diabetic patients was 7.4% (95% CI=4.71–10.08). Having multiple sexual
partners was significantly associated with HBV co-infection among diabetic
patients[AOR=2.92, 95% CI: 1.2–7.08].
Conclusion:Intermediate prevalence of HBV infection was reported among diabetic
patients.Therefore, systematic screening for HBsAg is recommended among diabetic patients
during their follow for a better outcome and to reduce the risk of HBV transmission.
