TREATMENT OUTCOME AND FACTORS ASSOCIATED WITH TREATMENT OUTCOMES OF FEMALE BREAST CANCER AMONG PATIENTS TREATED AT THE CANCER TREATMENT CENTER AT HIWOTFANACOMPREHENSIVE SPECIALIZED UNIVERSITY HOSPITAL, EASTERN ETHIOPIA

Abstract

Background:In Ethiopia breast cancer contributes around 33% of female cancer and there is still a significant difference in magnitude of mortality and morbidity in developing countries. But, there is little information on the magnitude and progress of female breast cancer in Ethiopia. Objectives: To assess treatment outcome and factors associated with treatment outcomes of female breast cancer among patients treated at the cancer treatment center at HiwotFana Specialized University Hospital, Eastern Ethiopia, from January 1, 2020, to December 31, 2022. Methods:Hospital-based retrospective cross-sectional study was conducted on the total of 295 female breast cancer patients. Data were collected from patient files including oncology ward logbook, major Operation Room logbooks and integrated individual patient folders from medical record.Allwomen diagnosed with breast cancer and started treatments at cancer treatment center from January 1, 2020 to December 31 were included. Candidate variables were included into logistic regression using stepwise backward elimination criteria(p-value< 0.2). Adjusted odds ratio with 95%CI was used to report effect of covariates and p-value <0.05 was used as cut off point for significance of the associations. Result: from the studied patients with breast cancer 85.1% were present with Histologic types ofInvasive ductalbreast carcinoma, 42.4% were stage IV breast cancer, and47.46% patients had metastasized.Overall mortality rate was 40 per 100 women with breast cancer diagnosed during study period. Mortality was higher among women with unknown receptor status (AOR:5.75; 95%CI:1.61, 20.53) and lower amongM0 stage tumor (AOR:0.03; 95%CI:0.01, 0.07) and who received combination of treatments (AOR: 0.14; 95%CI: 0.03, 0.67). Conclusion: The findings of this study revealedthat more than halfof thepatients with breast cancers had metastasis at the time of presentation.Similarly, the mortality rate was higher and associated with occupation, receptor status, and tumor size and treatment modalities.