Abstract:
Background: Unacceptably high levels of illness and mortality caused by malaria are worldwide 
public health concern. In Ethiopia, it is estimated that 68% of the population lives in areas where 
malaria is a concern, and that 75% of the country has malaria. Still, there is scarcity of data about 
malaria and factors associated with malaria infection in Dire Dawa City Administration, Eastern 
Ethiopia.
Objectives: To determine the prevalence of malaria and associated factors among symptomatic 
and asymptomatic patients in Dire Dawa, Eastern Ethiopia from December 1, 2023 to January 
31,2024.
Methods: Institution based comparative cross-sectional study was conducted among 578 
symptomatic and asymptomatic malaria patients in Goro heath center, Dire Dawa. Study 
participants who were attending the health facility during the study period were involved in the 
study consecutively. Two experienced nurses were participated in identifying symptomatic and 
asymptomatic participants. Capillary blood samples were collected and used to prepare thin and 
thick blood smears, which were then stained using 10% Giemsa and examined under light 
microscope. Epi info version 7.2 was used for data entry and Statistical Product and Service 
Solutions (SPSS) Version 27 for analysis. 
Results: The prevalence of malaria among symptomatic and asymptomatic patients was 19.4% 
(95% CI: 14.89-24.41) and 4.8% (95% CI:2.67-7.99), respectively. P. falciparum was the 
predominant species 6.57% (38) and P. vivax 5.54 % (32) from symptomatic group. Presence of 
stagnant water near residence was significantly associated with malaria 2.51 (AOR=2.51, 95% 
CI:1.24-5.08).
Conclusion: Malaria prevalence was high among symptomatic than asymptomatic participants. 
Presence of stagnant water near residence was significantly associated with malaria infection 
among symptomatic patients. Hence, this study recommends continued public health 
interventions targeting, drainage of stagnant water and improve public awareness about malaria 
transmission.